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Writer's pictureDr. ARUN V J

TME 13: A Lifesaving Symphony: A Brief History of Blood and Blood Transfusion

Updated: Mar 10

Introduction:

Blood, the crimson river coursing through our veins, has captivated the imagination of scientists, physicians, and healers throughout history. The story of blood and its transfusion is a tale of perseverance, discovery, and ultimately, lifesaving advancements. Join us on a journey through time as we unravel the fascinating history of blood and the evolution of blood transfusion.


A blood drop reading books in a library
History of blood is fascinating

Ancient Beliefs and Early Practices:

Blood has been intertwined with humans since ancient times. Men have since understood blood as the elixir of life and the role it played in sustaining life.

The ancient Egyptians believed that blood contained the essence of life, and they practiced the art of bloodletting to balance the body's vitality. Similarly, the Greeks and Romans explored the concept of vital fluids, influencing medical practices for centuries. However, it wasn't until the 17th century that the first recorded attempts at blood transfusion were made.

There were a lot of myths surrounding blood donation and it was rooted in ignorance and unawareness. There were customs of bathing in the blood of the young to rejuvenate yourselves, and drinking the blood of fallen enemies to consume their strength, all false beliefs.


Early Transfusion Attempts:

In 1665, Dr. Richard Lower, an English physician, performed the first successful blood transfusion between dogs. This groundbreaking experiment laid the foundation for further research into the possibility of transferring blood between animals and, eventually, humans.

A drawing of a man receiving blood from an animal
Richard Lower attempting animal to human blood transfusion

Human-to-Human Transfusions:

The 17th and 18th centuries saw sporadic attempts at human-to-human blood transfusions, often met with mixed success and significant risks. The lack of understanding regarding blood types and the immune system led to numerous complications and fatalities. There were many failed attempts at human transfusion leading to the death of many which in turn led to the banning of blood transfusion by the church.

In 1818, James Blundell did a recorded successful human-to-human transfusion from a husband to a wife who had bleeding during delivery. James Blundell developed an instrument called an impellor and gravitator to facilitate transfusion.

A drawing of a man donating blood to a women
James Blundell's first human to human transfusion

Discovery of Blood Types:

The turning point in the history of blood transfusion came in the early 20th century with the groundbreaking work of Karl Landsteiner. In 1901, Landsteiner identified and classified blood types into the A, B, and C groups (the C group later came to be known as the O group), revolutionizing the field of transfusion medicine. This discovery paved the way for safe and successful blood transfusions by matching donors and recipients based on blood compatibility.

A picture of Karl Landsteiner
Karl Landsteiner

World War and Blood Banking:

The urgency of medical care during World War I highlighted the need for organised blood transfusion services. The establishment of the first blood banks in the early 20th century allowed for the collection, storage, and safe distribution of blood, saving countless lives on the battlefield and beyond.

Every war pushed the need for blood and research was conducted to store blood for longer times. Transportation of blood to the battlefield became a problem and hence bottles, anticoagulants and other mechanisms were developed.


  • During the Spanish Civil War, the Republican Army banked 9000 litres of blood later administered at casualty stations and base hospitals (First Mobile Blood Bank, the 1930s).

  • Oswald Robertson, an American Army officer is credited with creating the blood depots. He received the AABB Landsteiner Award in 1958 as the developer of the first blood bank.

  • The first blood bank was established in Leningrad Hospital in 1932.



Blood Transfusion Today: Transfusion Medicine

In the modern era, blood transfusion has become a routine and lifesaving medical procedure. Advances in blood banking, storage techniques, and testing for infectious diseases have made transfusions safer and more accessible. Additionally, the development of synthetic blood substitutes and ongoing research into regenerative medicine holds promise for the future of transfusion medicine.

Blood Transfusion has become the backbone of the healthcare system. Organizations like the International Society of Blood Transfusion, Transfusion Medicine Academic Society, Indian Society of Transfusion Medicine, and Indian Society of Blood Transfusion and Immunohematology have been working to improve blood transfusion services around the globe.

A flowchart of history of blood
History of Blood 1
Flowchart showing history of blood
History of Blood 2

Conclusion:

The history of blood and blood transfusion is a testament to human curiosity, resilience, and the pursuit of medical progress. From ancient beliefs in the mystical properties of blood to the meticulous science of matching blood types, the journey has been marked by both triumphs and challenges. Today, blood transfusion stands as a cornerstone of modern medicine, embodying the collaborative efforts of countless individuals who dared to explore the mysteries of the vital fluid that sustains life.

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